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Side effects of antipsychotics

Side effects

Typical antipsychotics are sometimes classified, in the British National Formulary for example, by their side-effect profi le. This is dependent on their propensity to act not only as an antagonist at dopamine D2 receptors but at other dopamine receptors and other types of receptors such as alpha-1 adrenaline, H1 histamine and M1 acetylcholine receptors. These are predictable from the receptor-binding profi le of the drug and usually dose-dependent. Normal therapeutic ranges provide for maximum desired response. Prescribing in higher doses often merely leads to increased side effects.

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